Creatine is having a cultural moment. It’s one of the most studied performance supplements in the world - beloved for improving strength, muscle tone, cognitive performance, and even cellular energy. But for some people, creatine quietly brings an unwanted side effect: shedding.

Not everyone experiences it, but when they do, it’s confusing and discouraging. The fitness industry rarely talks about it. The beauty industry barely acknowledges it. Yet the mechanism is real, and understanding it will empower you to protect your hair while still enjoying the benefits of creatine without sacrificing your strands.

At Agent Nateur, we’re here to bring clarity, science, and solutions.

How Creatine Can Contribute to Hair Loss

Creatine does not directly “kill” hair follicles—but it *can influence the hormonal environment that affects hair growth.

1. The DHT Connection: studies show that creatine supplementation may increase dihydrotestosterone (DHT), a potent androgen that shortens the growth (anagen) phase of hair follicles.

When DHT rises:

• Hair becomes finer
• Follicles miniaturize
• Shedding accelerates
• The hairline may feel more fragile

Not everyone is DHT-sensitive. But if you are genetically prone, even a mild increase can tip your scalp into a shedding cycle.

2. Stress on the Nervous System and Cortisol: creatine enhances performance —especially during intense training. But high-intensity workouts spike cortisol, and cortisol is one of the most overlooked triggers of telogen effluvium (stress-induced shedding).

If creatine enables you to push harder in the gym, your scalp may feel the downstream effect.

3. Increased Metabolic Demand: creatine speeds ATP regeneration, but hair follicles require enormous energy. If your nutrient intake doesn’t rise to match that demand, your follicles may experience relative deficiency, especially in:

• sulfur amino acids
• silica precursors
• trace minerals
• collagen peptides

In other words: the body prioritizes your muscles before your hair.

How to Support Your Hair While Taking Creatine

You don’t have to stop creatine. You simply need to rebalance the environment that it disrupts—and that’s where the Agent Nateur hair-system becomes powerful.

Below is the Agent protocol we recommend for anyone taking creatine and experiencing shedding.

1. Rebuild the Hair Shaft and Follicle with holi (mane)

Marine collagen + pearl powder deliver the amino acids, minerals, and peptides creatine-users often become deficient in. holi (mane):

• strengthens the hair shaft to resist breakage
• supports keratin formation
• replenishes glycine, proline, and hydroxyproline
• provides ocean minerals and calcium from pearl to balance stress responses

Creatine increases metabolic turnover; holi (mane) restores what the follicle needs to keep growing.

Take it daily—creatine-related shedding responds beautifully to predictable collagen intake.

2. Protect the Dermal Matrix with holi (radiance)

This formula is your internal shield against stress-triggered hair loss.

MSM + ceramosides improve:

• collagen cross-linking
• follicle anchoring
• scalp barrier health
• inflammation driven by cortisol spikes

MSM also increases keratin flexibility and sulfur content in the hair—a crucial counterbalance, because creatine users often burn through sulfur amino acids more rapidly during training.

holi (radiance) strengthens the internal terrain so follicles stay anchored, nourished, and resilient.

3. Stimulate Regrowth with holi (growth) and holi (locks)

If creatine has triggered shedding, this topical treatment becomes essential.

Holi (growth) contains:

• Redensyl and Follicusan to signal follicle regrowth
• Copper peptides to reduce inflammation and extend the anagen phase.

holi (locks) contains DHT blockers like pumpkin oil and caffeine  

Apply holi (locks) twice daily or every other day from root to scalp. Most users report early results within 6–8 weeks.

Apply holi (locks) 1-2 times per week. Leave on overnight.

The Agent Nateur Hair-Strengthening Plan for Creatine Users

Morning: holi (radiance) + holi (mane) 

Post-shower: holi (growth) massaged into the hairline and thinning areas

Daily: Stay hydrated, increase protein, and support mineral balance (creatine increases cellular water demand)

Training Days: Avoid excessive high-intensity interval training if you’re in a shedding cycle; keep cortisol gentle

Evening: holi (growth) followed by holi (locks). Leave holi (locks) on overnight and wash the following day.

Creatine is not inherently harmful—but it can unmask hormonal and metabolic vulnerabilities that show up first in your hair. If you’re genetically sensitive to DHT or prone to stress-related shedding, creatine may accelerate what was already brewing beneath the surface.

With the right nutritional and topical support, your hair does not have to pay the price for your strength or performance.

• holi (mane) fortifies your protein matrix.
• holi (radiance) protects your internal terrain.
• holi (growth) stimulates regrowth and safeguards your scalp.

You can consider saw palmetto both topically and orally, but it should be avoided during pregnancy and breastfeeding, and it may influence hormone levels in some individuals.

Natural DHT blockers beyond saw palmetto focus on gently modulating 5-alpha-reductase activity, reducing oxidative stress, and supporting healthy hormone balance. Stinging nettle root helps limit the conversion of testosterone to DHT while also reducing scalp inflammation. Pumpkin seed oil contains phytosterols that have been shown to lower DHT activity and support hair density. Green tea extract (EGCG) inhibits 5-alpha-reductase and protects hair follicles through its antioxidant and anti-inflammatory effects. Pygeum africanum bark extract supports prostate and hormonal health by reducing DHT binding to receptors. Reishi mushroom has been studied for its ability to suppress 5-alpha-reductase while calming stress-related cortisol, which indirectly supports healthier androgen balance. Together, these botanicals offer a more holistic, non-aggressive approach to managing DHT without disrupting overall hormone function.